Lizzo Responds to South Park Naming an Ozempic Alternative After Her: ‘My Worst Fear’

The show’s latest special featured a faux medication called “Lizzo,” which helps users “feel good” about their weight.

Lizzo’s “worst fear” just became a reality — she was featured on South Park.

The latest special episode, South Park: The End of Obesity, aired on May 24 and tackled the increasing use of Ozempic. In a humorous twist, the episode introduced a faux medication named after the singer, who has long been an advocate for body positivity.

The day after the episode aired, the 36-year-old artist took to TikTok to share her “blind duet” reaction. Starting her video, she announced: “Guys, my worst fear has been actualized. I’ve been referenced in a South Park episode.”

“I’m so scared,” Lizzo added, as she continued to react to this notable — if nerve-wracking — milestone, which began with a conversation between Sharon and Sheila, the moms of main characters, Stan and Kyle.

In the episode, Sharon tells Sheila that her doctor won’t prescribe weight loss medications like Ozempic because she isn’t diabetic. Sheila is curious about how Sharon manages her weight without such drugs.

“Don’t you know, Sheila? Now, there’s a new obesity drug for those of us who can’t afford Ozempic and Mounjaro,” Sharon explains.

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Sharon then says, “I controlled all my cravings to be thinner with Lizzo,” leading the real Lizzo to drop her jaw and cover her mouth in surprise.

The episode continues with a parody of overly positive medication ads. The narrator elaborates that this faux drug “makes you feel good about your weight — and it costs 90% less than Ozempic.”

As the spoof commercial progresses, and Sharon chimes in with, “I’ve lowered my standards and my expectations,” Lizzo appeared in shock, still covering her mouth.

Elsewhere in the faux drug ad, the narrator claims the medication allows users to indulge in their favorite foods with minimal exercise and states “70% of patients on Lizzo no longer care how much they weigh.”

The commercial then features a character listening to a Lizzo album, prompting the singer to exclaim, “Not the album!”

As Sharon wraps up the ad by saying, “Ask about the power of not giving a f— with Lizzo,” the singer approves with a snap and says, “Period.”

When the clip concluded, Lizzo commented, “That’s crazy. I just feel like, damn, I’m really that!”

“I really showed the world how to love yourself and not give a f—,” she added, noting that South Park creators Trey Parker and Matt Stone took notice. “To the point where these men in Colorado know who I am and put it on their cartoon that’s been around for 25 years.”

“And I’m going to keep on showing you how to not give a f—,” she added before wrapping up her video with her own version of the faux commercial’s jingle.

South Park: The End of Obesity is now available for streaming on Paramount+.


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